Blood Coagulation or Clotting Factors are the natural proteins which help in coagulation of blood to control bleeding, they also help to maintain the flow of blood in the body and also make sure coagulation takes place in case of any injury. In simple words Coagulation means Clotting which is seen when there is any injury to the body, the Liquid blood turns in gel form which is used to stop the bleeding from the injury site. The Clotting factors are Plasma proteins which are circulating in the Blood stream, they end up being a clot through Enzymatic cascade. Most have their own role to play in Clotting, but some Factors play a major role – Thrombin (Factor II) which is a major coagulant as it converts Fibrinogen into Fibrin which forms a major chunk of the Clot in addition to the Platelets.
13 Blood Clotting Factors in Human Body:
Factor I = Fibrinogen
Factor II = Prothrombin
Factor III = Tissue Thromboplastin
Factor IV = Calcium
Factor V = Proaccelerin, Labile factor
Factor VI – Accelerin (Does not exist as it was named initially but later on discovered not to play a part in blood coagulation)
Factor VII = Serum Prothrombin, Stable factor antihemophilic
Factor VIII = Antihemophilic factor A, Antihemophilic Globulin, Antihemophilic factor
Factor IX = Plasma Thromboplastin component, Antihemophilic factor B or Christmas factor
Factor X = Stuart Prower factor
Factor XI = Antihemophilic factor C
Factor XII = Hageman factor
Factor XIII = Fibrin stabilizing factor
Mnemonic for 13 Clotting Factors:
Mnemonic is used to help the student or Doctor make it easy to remember any specific or complicated list of content.
Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen
Factor I – Foolish – Fibrinogen
Factor II – People – Prothrombin
Factor III – Try – Tissue Thromboplastin
Factor IV – Climbing – Calcium
Factor V – Long – Labile factor (Proaccelerin)
Factor VI – Accelerin (Does not exist as it was named initially but later on discovered not to play a part in blood coagulation)
Factor VII – Slopes – Stable factor antihemophilic (Serum Prothrombin)
Factor VIII – After – Antihemophilic factor A, Antihemophilic Globulin, Antihemophilic factor
Factor IX – Christmas – Christmas factor
Factor X – Some – Stuart Prower factor
Factor XI – People – Plasma Thromboplastin Antecedent (Antihemophilic factor C)
Factor XII – Have – Hageman factor
Factor XIII – Fallen – Fibrin stabilizing factor
There is another Mnemonic which can be used for remembering the 13 Clotting Factors –
“Freshers Party Tonight Come Lets Sing And Call Seniors Please Have Fun”
Knowing about the Blood Coagulation factors in Dentistry is very important to prevent the mishaps from occurring during or after Dental procedures. There are many Hematologic disorders which are related to these factors, which makes it essential to make note of these factors and the concerning disorders.
well they are I~XIII … Well I will tell u more details after physiology examination on 19.02.2011 because I would be studied in details and Ill give u more specific answer
This is very imp in lab
Very nice